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Introduction
Down syndrome is a genetically originated developmental pathology involving multi-organ and multi-level human development dysfunction, occurring in 1 for 700 born neonates with increasing frequency in the last decades, due to advancement in medical sciences. Genetic disorders determine the set of symptoms of moderate or deep mental retardation, which affect development of different spheres of the child: psychosomatic, intellectual, emotional, social behavior, communication, and personality development. Down syndrome is a multiform disorder and any therapy program used should provide multidirectional support, according to the child’s general genetic pathological mechanisms and their individual development. The current study demonstrates significant improvement of functioning of reflex patterns in children with Down syndrome as verified by mathematical statistical analysis. Presenting the model of the evaluation of reflex pattern development according to the mathematical statistical analysis by synthesized Z function by A. Krefft allows for an objective approach and scientific analysis of the effectiveness of the MNRI® program designed for 8 days at Therapeutic Rehabilitation Camps in Poland, Canada, and the US.

Specifics of the Development of Children with Down Syndrome
Down syndrome is a genetically determined, permanent, and incurable development disorder. However, the primary motor coordination disorders and acquired patterns can be improved or corrected (Sadowska, Masgutova, Kowalewska, 2009). Repatterning offers one such possibility. A priority in the purpose of MNRI® therapy is improvement of functioning of reflex patterns and their integration in a general child’s static-motor system, facilitation of brain functioning plasticity, plasticity of neurodevelopment, and activation of the emotional, social, and cognitive processes.

Infant reflex patterns of a child with Down syndrome are usually developed poorly and it takes more effort and time to trigger and activate their functioning. The development of reflexes of these children is delayed. The reasons for this are some specific physical and somatic features as well as specific functioning of their central nervous system. Most children after birth have poor muscle tone control (hypo-tonicity), general flaccidity, lower muscle strength, and excessive/hyper motor rotation range in their joints. Characteristic physical features for Down syndrome can cause developmental dysfunctions and deficits in reflex patterns integration as well as a child’s motor and cognitive functioning.

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